Literature summary for 3.4.21.5 extracted from

Sekine, O.; Sugo, T.; Ebisawa, K.; Umeyama, H.; Iwahana, H.; Ruiz-Saez, A.; de Bosch, N.; Matsudai, M.
Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perija leads to the loss of thrombin proteolytic activity (2002), Thromb. Haemost., 87, 282-287.

Search for more literature for 3.4.21.5

Cloned(Commentary)

Cloned (Comment)	Organism
DNA sequence determination of the natural mutant gene	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G548A	naturally occuring mutant, substrate binding pocket mutation, loss of proteolytic activity against native substrates fibrinogen, protein C, and synthetic substrates, reduced ability to bind antithrombin III, causes dysprothrombinemia	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	plasma	Homo sapiens	-	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
72000	-	x * 72000, enzyme mutant, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human mutant with homozygous dysprothrombinemia with a low level of coagulation activity, prothrombin Perija	-

Purification (Commentary)

Purification (Comment)	Organism
dysprothrombin Perija	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
plasma	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 72000, enzyme mutant, SDS-PAGE	Homo sapiens
More	structure analysis of the mutant enzyme	Homo sapiens

Synonyms

Synonyms	Comment	Organism
alpha-thrombin	-	Homo sapiens

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Release 2023.1 (January 2023)