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Literature summary for 3.4.21.47 extracted from

  • Di Fede, M.; Biagini, M.; Cartocci, E.; Parillo, C.; Greco, A.; Martinelli, M.; Marchi, S.; Pezzicoli, A.; Delany, I.; Rossi Paccani, S.
    Neisseria heparin binding antigen is targeted by the human alternative pathway C3-convertase (2018), PLoS ONE, 13, e0194662 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
C2 fragment + H2O Homo sapiens C-terminal fragment originating from the processing of meningococcal proteases ?
-
?
complement component C3 + H2O Homo sapiens
-
complement component C3a + complement component C3b
-
?
neisserial heparin binding antigen + H2O Homo sapiens also known as GNA2132 (genome-derived Neisseria antigen 2132) ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Calu-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
C2 fragment + H2O C-terminal fragment originating from the processing of meningococcal proteases Homo sapiens ?
-
?
complement component C3 + H2O
-
Homo sapiens complement component C3a + complement component C3b
-
?
neisserial heparin binding antigen + H2O also known as GNA2132 (genome-derived Neisseria antigen 2132) Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alternative pathway C3-convertase
-
Homo sapiens