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Literature summary for 3.4.21.47 extracted from

  • Fridkis-Hareli, M.; Storek, M.; Or, E.; Altman, R.; Katti, S.; Sun, F.; Peng, T.; Hunter, J.; Johnson, K.; Wang, Y.; Lundberg, A.S.; Mehta, G.; Banda, N.K.; Michael Holers, V.
    The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models (2019), Mol. Immunol., 105, 150-164 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
soluble complement receptor type 1
-
 Homo sapiens
TT30 complement alternative pathway-selective inhibitor, fusion protein linking the first four short consensus repeats of human complement receptor type 2 with the first five short consensus repeats of human factor H Homo sapiens
TT32 human complement receptor type 2 (CR2)/CR1 fusion protein Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens
-
 complement component C3a + complement component C3b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?

Synonyms

Synonyms Comment Organism
alternative pathway C3 convertase
-
 Homo sapiens
AP C3 convertase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
 at 37°C, pH not specified in the publication Homo sapiens soluble complement receptor type 1
0.000046
-
 at 37°C, pH not specified in the publication Homo sapiens TT32
0.00013
-
 at 37°C, pH not specified in the publication Homo sapiens TT30