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Literature summary for 3.4.21.47 extracted from

  • Heesterbeek, D.; Bardoel, B.; Parsons, E.; Bennett, I.; Ruyken, M.; Doorduijn, D.; Gorham, R.J.; Berends, E.; Pyne, A.; Hoogenboom, B.; Rooijakkers, S.
    Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases (2019), EMBO J., 38, e99852 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293E cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C5 + H2O Homo sapiens
-
 complement component C5a + complement component C5b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
C5 convertase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function both the in situ conversion of complement component C5 by the enzyme and immediate association of C5b with C6 and C7 are needed to guide proper insertion of bactericidal MAC pores Homo sapiens