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Literature summary for 3.4.21.47 extracted from

  • Berends, E.T.; Gorham, R.D.; Ruyken, M.; Soppe, J.A.; Orhan, H.; Aerts, P.C.; de Haas, C.J.; Gros, P.; Rooijakkers, S.H.
    Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes (2015), BMC Biol., 13, 93 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.47

Activating Compound

Activating Compound Comment Organism Structure
additional information high surface density of complement component C3b is critical for the enzyme activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
eculizumab
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C5 + H2O Homo sapiens
-
 complement component C5a + complement component C5b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
alternative pathway C5 convertase
-
 Homo sapiens
AP C5 convertase
-
 Homo sapiens
C5 convertase
-
 Homo sapiens
complement C5 convertase
-
 Homo sapiens