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Literature summary for 3.4.21.47 extracted from

  • Kimura, Y.; Miwa, T.; Zhou, L.; Song, W.C.
    Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement (2008), Blood, 111, 732-740.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.47

Activating Compound

Activating Compound Comment Organism Structure
properdin facilitates AP complement activation by stabilizing the C3 convertase C3bBb, essential for AP complement activation induced by bacterial lipopolysacharide (LPS) and lipooligosacharide (LOS) and other AP complement activators Homo sapiens
properdin facilitates AP complement activation by stabilizing the C3 convertase C3bBb, essential for AP complement activation induced by bacterial lipopolysacharide (LPS) and lipooligosacharide (LOS) and other AP complement activators Mus musculus

Application

Application Comment Organism
medicine studies on role of properdin in AP complement initiation for understanding the selective predisposition of properdin-deficient patients to meningococcal infection Homo sapiens
medicine studies on role of properdin in AP complement initiation for understanding the selective predisposition of properdin-deficient patients to meningococcal infection Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens
-
 complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O Mus musculus
-
 complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O Homo sapiens
-
 complement component C5a + complement component C5b
-
 ?
complement component C5 + H2O Mus musculus
-
 complement component C5a + complement component C5b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00751
-
-
Mus musculus P04186
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-
serum
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 ability of human properdin to restore LPS-dependent AP complement activity in properdin-deficient mouse serum shown to be correlated with the human properdin-binding affinity of the LPS Homo sapiens
additional information
-
 LPS- and LOS-induced AP complement activation abolished in properdin-deficient mouse serum, zymosan- and cobra venom factor-induced AP complement activation observed, classical pathway-triggered AP complement amplification only partially or minimally affected in properdin-deficient mice, ability of human properdin to restore LPS-dependent AP complement activity in properdin-deficient mouse serum shown to be correlated with the human properdin-binding affinity of the LPS Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O
-
 Mus musculus complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O complement activation in properdin-deficient mice analyzed Mus musculus complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O properdin-deficient patients susceptible to lethal meningococcal infection, studies on yet unknown mechanism of selective predisposition Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?
complement component C5 + H2O
-
 Mus musculus complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
alternative-complement-pathway C3/C5 convertase
-
 Homo sapiens
alternative-complement-pathway C3/C5 convertase
-
 Mus musculus