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BRENDA support

Literature summary for 3.4.21.47 extracted from

  • Selander, B.; Martensson, U.; Weintraub, A.; Holmstroem, E.; Matsushita, M.; Thiel, S.; Jensenius, J.C.; Truedsson, L.; Sjoeholm, A.G.
    Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 (2006), J. Clin. Invest., 116, 1425-1434.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.47

Activating Compound

Activating Compound Comment Organism Structure
mannan-binding lectin binding to O antigen-specific oligosaccharides derived from Salmonella sp. corresponding to serogroup C, and efficient support of component C3 deposition in the absence of C2, C4, or the associated serine protease 2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 component C2-deficient patient
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Source Tissue

Source Tissue Comment Organism Textmining
serum existence of a mannan-binding lectin-dependent C2 bypass mechanism for alternative pathway-mediated C3 activation Homo sapiens
-