Literature summary for 3.4.21.46 extracted from

Liu, G.; Changsirikulchai, S.; Hudkins, K.L.; Banas, M.C.; Kowalewska, J.; Yang, X.; Wietecha, T.A.; Volpone, J.; Gilbertson, D.G.; Alpers, C.E.
Identification of platelet-derived growth factor D in human chronic allograft nephropathy (2008), Hum. Pathol., 39, 393-402.

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Application

Application	Comment	Organism
medicine	PDGF-D is present in the neointima of the arteriopathy of chronic allograft nephropathy, where it can engage PDGF-Rbeta to promote mesenchymal cell migration, proliferation, and neointima formation. PDGF-D may engage the PDGF-Rbeta to promote interstitial injury in chronic allograft injury	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	PDGF-D is expressed uniformly in the cytoplasm of medial smooth muscle cells of the arteries and variably by some adventitial cells. PDGF-D expression is present in the epithelial cytoplasm of some, but not all, distal tubules and collecting ducts and in podocytes	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	PDGF-D is widely expressed in most neointimas in arteries exhibiting the chronic arteriopathy of chronic allograft nephropathy and is only weakly expressed in a small proportion of sclerotic arteries. The neointimal cells expressing PDGF-D are alpha-smooth muscle actin-expressing cells, but not infiltrating macrophages or endothelial cells	Homo sapiens	-
kidney	PDGF-D is uniformly expressed in visceral epithelial cells and arteriolar wall in normal kidneys, kidneys with acute vascular rejection, and kidneys with chronic allograft nephropathy. In kidneys with acute vascular rejection, PDGF-D is expressed in arterial medial smooth muscle cells, some adventitial cells, and some neointimal cells that also have alpha-smooth muscle actin expression	Homo sapiens	-
additional information	present in distal tubule and duct. Absent from proximal tubule and interstitium	Homo sapiens	-
podocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PDGF-D	-	Homo sapiens
platelet-derived growth factor D	-	Homo sapiens

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Release 2023.1 (January 2023)