Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | A direct repeat element located in the proximal human vegf-D gene promoter, consisting of a consensus half-site (AGGTCA) at -125/-119 and a degenerated direct repeat half-site (ATGTTA) at -99/-94 is sufficient and necessary for vegf-D transcription. The vegf-D direct repeat element is bound and activated by the orphan receptors hepatocyte nuclear factor 4A and chicken ovalbumin upstream promoter transcription factor 1 and 2 as well as transcriptional coactivators glucocorticoid receptor interacting protein 1 and cyclic AMP-responsive element binding protein-binding protein to drive vegf-D gene transcription. Histone deacetylase inhibition by trichostatin A leads to accumulation of acetylated histones H3/H4 at the vegf-D promoter, up-regulation of vegf-D mRNA levels, and transactivation of vegf-D promoter reporter gene constructs in cancer cell lines | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | is linked to the control of lymphangiogenesis and lymphatic metastasis. Epigenetic control of histone acetylation represents an important determinant of vegf-D gene expression in cancer cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gastric cells transiently transfected with the pGL3-based vegf-D reporter gene construct vegf-D(-2011/+110), which comprises nucleotides -2011/+110 of the human vegf-D gene | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AGS cell | low levels of vegf-D mRNA | Homo sapiens | - |
gastric cell line | - |
Homo sapiens | - |
KATO-III cell | low levels of vegf-D mRNA | Homo sapiens | - |
MKN-28 cell | low levels of vegf-D mRNA | Homo sapiens | - |
MKN-45 cell | 5- to 8fold higher amounts of vegf-D mRNA as the other gastric cell lines | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
vascular endothelial growth factor D | - |
Homo sapiens |
VEGF-D | - |
Homo sapiens |