BRENDA - Enzyme Database show
show all sequences of 3.4.21.46

Maternal transfer of complement components C3-1, C3-3, C3-4, C4, C5, C7, Bf, and Df to offspring in rainbow trout (Oncorhynchus mykiss)

Lovoll, M.; Kilvik, T.; Boshra, H.; Bogwald, J.; Sunyer, J.O.; Dalmo, R.A.; Immunogenetics 58, 168-179 (2006)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
290000
-
SDS-PAGE
Oncorhynchus mykiss
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
complement factor B + H2O
Oncorhynchus mykiss
-
Bb fragment + Ba fragment
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oncorhynchus mykiss
-
rainbow trout
-
Purification (Commentary)
Commentary
Organism
gel filtration
Oncorhynchus mykiss
Source Tissue
Source Tissue
Commentary
Organism
Textmining
egg
unfertilized
Oncorhynchus mykiss
-
embryo
hatchling; transcript levels steadily increased from day 28 post-fertilization to hatch
Oncorhynchus mykiss
-
heart
-
Oncorhynchus mykiss
-
intestine
-
Oncorhynchus mykiss
-
kidney
-
Oncorhynchus mykiss
-
liver
-
Oncorhynchus mykiss
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
immunohistological detection between day 7 and 35 post-fertilization, transcripts detected at day 28, peaking at day 84 and 98 post-fertilization; immunohistological detection in homogenates from all sampled time-points including day 0 post-fertilization, transcripts detected at day 28, peaking at day 84 and 98 post-fertilization; protein not detected until day 77 post-fertilization, transcription starting at day 28 and peaking at day 84 and 98 post-fertilization; transcript levels steadily increased from day 28 post-fertilization to hatch, immunohistological detection of Df protein in homogenates from all sampled time-points including day 0 post-fertilization; transcripts of complement factor D steadily increased from day 28 post-fertilization to hatch, mRNA detected at day 28, peaking at day 84 and 98 post-fertilization observed, immunohistological detection of Df protein in homogenates from all sampled time-points including day 0 post-fertilization
Oncorhynchus mykiss
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
complement factor B + H2O
-
683526
Oncorhynchus mykiss
Bb fragment + Ba fragment
-
-
-
?
complement factor B + H2O
expression patterns of complement factor D during development of Oncorhynchus mykiss analyzed, maternal transfer suggested
683526
Oncorhynchus mykiss
Bb fragment + Ba fragment
-
-
-
?
complement factor B + H2O
expression patterns of complement factor D during development studied, maternal transfer suggested
683526
Oncorhynchus mykiss
Bb fragment + Ba fragment
-
-
-
?
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
290000
-
SDS-PAGE
Oncorhynchus mykiss
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
complement factor B + H2O
Oncorhynchus mykiss
-
Bb fragment + Ba fragment
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
gel filtration
Oncorhynchus mykiss
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
egg
unfertilized
Oncorhynchus mykiss
-
embryo
hatchling; transcript levels steadily increased from day 28 post-fertilization to hatch
Oncorhynchus mykiss
-
heart
-
Oncorhynchus mykiss
-
intestine
-
Oncorhynchus mykiss
-
kidney
-
Oncorhynchus mykiss
-
liver
-
Oncorhynchus mykiss
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
immunohistological detection between day 7 and 35 post-fertilization, transcripts detected at day 28, peaking at day 84 and 98 post-fertilization; immunohistological detection in homogenates from all sampled time-points including day 0 post-fertilization, transcripts detected at day 28, peaking at day 84 and 98 post-fertilization; protein not detected until day 77 post-fertilization, transcription starting at day 28 and peaking at day 84 and 98 post-fertilization; transcript levels steadily increased from day 28 post-fertilization to hatch, immunohistological detection of Df protein in homogenates from all sampled time-points including day 0 post-fertilization; transcripts of complement factor D steadily increased from day 28 post-fertilization to hatch, mRNA detected at day 28, peaking at day 84 and 98 post-fertilization observed, immunohistological detection of Df protein in homogenates from all sampled time-points including day 0 post-fertilization
Oncorhynchus mykiss
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
complement factor B + H2O
-
683526
Oncorhynchus mykiss
Bb fragment + Ba fragment
-
-
-
?
complement factor B + H2O
expression patterns of complement factor D during development of Oncorhynchus mykiss analyzed, maternal transfer suggested
683526
Oncorhynchus mykiss
Bb fragment + Ba fragment
-
-
-
?
complement factor B + H2O
expression patterns of complement factor D during development studied, maternal transfer suggested
683526
Oncorhynchus mykiss
Bb fragment + Ba fragment
-
-
-
?
Other publictions for EC 3.4.21.46
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732521
Cresci
Alternative complement pathway ...
Mus musculus, Mus musculus C57BL/6
Mol. Immunol.
64
9-17
2015
-
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141
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2
2
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731071
Forneris
Ensemble refinement shows conf ...
Homo sapiens
Acta Crystallogr. Sect. D
70
733-743
2014
1
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1
1
3
-
1
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1
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2
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1
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1
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2
2
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732272
Degn
The pro-Factor D cleaving acti ...
Mus musculus
J. Immunol.
192
5448-5449
2014
-
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1
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3
3
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732044
Katschke
Inhibiting alternative pathway ...
Homo sapiens, Macaca fascicularis
J. Biol. Chem.
287
12886-12892
2012
-
2
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2
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2
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2
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3
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1
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2
2
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707940
Ahmad
Platelet-derived growth factor ...
Homo sapiens
Breast Cancer Res. Treat.
126
15-25
2011
-
-
1
-
-
-
-
-
-
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-
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1
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4
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1
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4
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2
1
1
2
-
-
708769
Hu
Deguelin-an inhibitor to tumor ...
Homo sapiens
Int. J. Cancer
127
2455-2466
2010
-
1
-
-
-
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3
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1
-
-
1
-
-
709321
Takahashi
Essential role of mannose-bind ...
Mus musculus
J. Exp. Med.
207
29-37
2010
-
-
-
-
-
-
-
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-
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3
-
1
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1
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-
718398
Forneris
Structures of C3b in complex w ...
Homo sapiens
Science
330
1816-1820
2010
-
-
1
1
6
-
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-
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-
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-
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1
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1
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2
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1
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1
6
-
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1
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2
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-
-
-
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-
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-
-
-
-
-
-
695580
Li
Vascular endothelial growth fa ...
Homo sapiens
Anat. Rec. (Hoboken)
292
562-569
2009
-
1
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
1
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1
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2
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1
-
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-
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-
-
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-
-
-
-
-
-
-
-
-
-
698902
Toivanen
Novel vascular endothelial gro ...
Homo sapiens
J. Biol. Chem.
284
16037-1648
2009
-
-
1
-
13
-
-
-
-
-
-
-
-
2
-
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1
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1
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1
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13
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1
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1
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-
699302
Kinnunen
Baculovirus is an efficient ve ...
Homo sapiens
J. Gene Med.
11
382-389
2009
1
1
1
-
-
-
-
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-
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4
-
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2
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2
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708131
Glasgow
Serum vascular endothelial gro ...
Homo sapiens
Chest
135
1293-1300
2009
-
1
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2
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1
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1
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1
1
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-
708370
Ming
Interleukin 7/interleukin 7 re ...
Homo sapiens
Eur. J. Cancer
45
866-873
2009
-
-
-
-
-
-
-
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2
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3
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3
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-
-
1
1
1
1
-
-
708533
Kong
An immune responsive complemen ...
Paralichthys olivaceus
Fish Shellfish Immunol.
27
486-492
2009
-
-
-
-
-
-
-
-
-
-
1
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8
-
1
-
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8
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1
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1
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8
-
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1
-
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1
-
-
710586
Deng
Vascular endothelial growth fa ...
Homo sapiens
Surgery
146
896-905
2009
-
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2
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1
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1
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1
1
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697096
Schaefer
Regulation of vascular endothe ...
Homo sapiens
Cancer Res.
68
457-466
2008
1
1
1
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3
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7
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1
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7
-
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698194
Liu
Identification of platelet-der ...
Homo sapiens
Hum. Pathol.
39
393-402
2008
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1
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683539
Luginbuehl
Complement factor D, albumin, ...
Homo sapiens
Infect. Immun.
75
1771-1777
2007
-
-
-
-
-
-
-
-
-
-
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1
-
3
-
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1
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1
1
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1
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1
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1
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1
1
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
668074
Sprong
Deficient alternative compleme ...
Homo sapiens
Blood
107
4865-4870
2006
-
-
-
-
2
-
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-
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-
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3
-
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1
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2
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1
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683526
Lovoll
Maternal transfer of complemen ...
Oncorhynchus mykiss
Immunogenetics
58
168-179
2006
-
-
-
-
-
-
-
-
-
-
1
1
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4
-
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1
-
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6
1
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3
-
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1
1
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1
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6
1
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3
-
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-
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-
-
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-
669356
Harris
Molecular dissection of intera ...
Homo sapiens
J. Biol. Chem.
280
2569-2578
2005
-
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1
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1
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1
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1
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1
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1
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