Activating Compound | Comment | Organism | Structure |
---|---|---|---|
beta1H | potentiates the action of the enzyme on C3b | Homo sapiens | |
C4-binding protein | cofactor | Homo sapiens |
General Stability | Organism |
---|---|
stable to 0.15 M hydrazine or 2 M guanidine-HCl | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | 10 mM, strong | Homo sapiens | |
dithiothreitol | 1 mM, strong | Homo sapiens | |
NEM | 1 mM, partial inhibition | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38000 | - |
1 * 38000 + 1 * 50000, non-catalytic 50000 Da subunit is disulfide-linked to the 38000 Da catalytic subunit | Homo sapiens |
50000 | - |
1 * 38000 + 1 * 50000, non-catalytic 50000 Da subunit is disulfide-linked to the 38000 Da catalytic subunit | Homo sapiens |
88000 | - |
sucrose density gradient centrifugation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | carbohydrate content is at least 10.7% w/w, not including neuraminic acid, with 7.2% hexose and 3.2% glucosamine | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
4°C, neutral pH, stable for several weeks | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3b + H2O | - |
Homo sapiens | complement component C3c + ? | - |
? | |
complement component C4b + H2O | - |
Homo sapiens | complement component C4c + C4d | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 38000 + 1 * 50000, non-catalytic 50000 Da subunit is disulfide-linked to the 38000 Da catalytic subunit | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
56 | - |
30 min, stable | Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
2.2 | - |
stable | Homo sapiens |