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Literature summary for 3.4.21.45 extracted from

  • Tsiftsoglou, S.A.; Willis, A.C.; Li, P.; Chen, X.; Mitchell, D.A.; Rao, Z.; Sim, R.B.
    The catalytically active serine protease domain of human complement factor I (2005), Biochemistry, 44, 6239-6249.
    View publication on PubMed
Search for more literature for 3.4.21.45

Inhibitors

Inhibitors Comment Organism Structure
4-(2-aminoethyl)benzenesulfonyl fluoride 0.25 mM, inhibits SP domain form and fI Homo sapiens
antipain 0.1 mM, inhibits SP domain form and fI Homo sapiens
Aprotinin 0.005 mM, inhibits SP domain form and fI Homo sapiens
factor H inhibits SP domain form Homo sapiens
leupeptin 0.01 mM, inhibits SP domain form and fI Homo sapiens
suramin 1 mM, inhibits fI Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 SP-domain-form, SDS-PAGE Homo sapiens
88000
-
 fI, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3(NH3) + H2O Homo sapiens cleaved by SP domain-form ?
-
 ?
complement component C3b + H2O Homo sapiens
-
 complement component iC3b a major opsonin ?
complement component C4b + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
generation of intact form of SP domain, purifiaction by affinity chromatography on MRC-OX21-Sepharose Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3(NH3) + H2O cleaved by SP domain-form Homo sapiens ?
-
 ?
complement component C3b + H2O
-
 Homo sapiens complement component iC3b a major opsonin ?
complement component C4b + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
factor I
-
 Homo sapiens
fI
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
additional information complement component C4bp Homo sapiens
additional information complement receptor 1 Homo sapiens
additional information factor H Homo sapiens
additional information membrane cofactor protein Homo sapiens