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Literature summary for 3.4.21.43 extracted from

  • Rawal, N.; Rajagopalan, R.; Salvi, V.P.
    Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP) (2009), Mol. Immunol., 46, 2902-2910.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.43

Inhibitors

Inhibitors Comment Organism Structure
C4b-binding protein regulates assembly and decay of the classical pathway C3/C5 convertase 4times lower than the lectin pathway convertase Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Ovis aries complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Ovis aries complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
classical pathway C3/C5 convertase
-
 Ovis aries
high affinity C5 convertase EAC1,C3bC4b,C2a Ovis aries
soluble C3 convertase C4b,C2a Ovis aries
surface-bound C3 convertase EAC1,C4b,C2a Ovis aries

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
 IC50 for the inhibition of formation of soluble C3 convertase (C4b,C2a) Ovis aries C4b-binding protein
0.000011
-
 IC50 for the acceleration of decay of surface-bound C3 convertase (EAC1,C4b,C2a) Ovis aries C4b-binding protein
0.000017
-
 IC50 for the acceleration of decay of soluble C3 convertase (C4b,C2a) Ovis aries C4b-binding protein
0.00002
-
 IC50 for the acceleration of decay of high affinity C5 convertase (EAC1,C3bC4b,C2a) Ovis aries C4b-binding protein
0.000035
-
 IC50 for the inhibition of formation of surface-bound C3 convertase (EAC1,C4b,C2a) Ovis aries C4b-binding protein
0.000072
-
 IC50 for the inhibition of formation of high affinity C5 convertase (EAC1,C3bC4b,C2a) Ovis aries C4b-binding protein