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Literature summary for 3.4.21.43 extracted from

  • Kuttner-Kondo, L.; Hourcade, D.E.; Anderson, V.E.; Muqim, N.; Mitchell, L.; Soares, D.C.; Barlow, P.N.; Medof, M.E.
    Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases (2007), J. Biol. Chem., 282, 18552-18562.
    View publication on PubMed
Search for more literature for 3.4.21.43

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C5 + H2O Homo sapiens C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b followed by initiation of the terminal pathway, leading to formation of lytic C5b-9 membrane attack complexes, overview complement component C5a + complement component C5b
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 ?
complement componentC3 + H2O Homo sapiens C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview complement component C3a + complement component C3b
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 ?
additional information Homo sapiens the C3 convertases, bimolecular complexes C4b2a and C3bBb, of the classical and alternative pathways are the central enzymes of the complement cascade, focused complement activation on foreign targets depends on regulatory proteins that decay the bimolecular C3 convertases, activity and regulation of complement control proteins CCP1-CCP4 as modules of the cell surface regulator, decay-accelerating factor, i.e. DAF or CD55, interaction of DAF with the convertases is mediated predominantly by two patches, one centered around Arg69 and Arg96 on CCP2 and the other around Phe148 and Leu171 on CCP3, structure, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b followed by initiation of the terminal pathway, leading to formation of lytic C5b-9 membrane attack complexes, overview Homo sapiens complement component C5a + complement component C5b
-
 ?
complement component C5 + H2O C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview Homo sapiens complement component C5a + complement component C5b
-
 ?
complement componentC3 + H2O C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview Homo sapiens complement component C3a + complement component C3b
-
 ?
additional information the C3 convertases, bimolecular complexes C4b2a and C3bBb, of the classical and alternative pathways are the central enzymes of the complement cascade, focused complement activation on foreign targets depends on regulatory proteins that decay the bimolecular C3 convertases, activity and regulation of complement control proteins CCP1-CCP4 as modules of the cell surface regulator, decay-accelerating factor, i.e. DAF or CD55, interaction of DAF with the convertases is mediated predominantly by two patches, one centered around Arg69 and Arg96 on CCP2 and the other around Phe148 and Leu171 on CCP3, structure, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
C3 convertase
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 Homo sapiens
C3bBb
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 Homo sapiens
C4b2a
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 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens