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Literature summary for 3.4.21.43 extracted from

  • Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
    Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway (2007), Int. Immunol., 19, 141-149.
    View publication on PubMed
Search for more literature for 3.4.21.43

Activating Compound

Activating Compound Comment Organism Structure
additional information cooperation of the enzyme with MBL-associated serine proteases MASP-1 and MASP-2 in C3 cleavage, the serine proteases generate active C3 convertase at high serum concentration, while MASP-3 inhibits it, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens C3 complement cleavage is a central event in the activation of the complement system via the classical, the alternative, and the lectin pathway, overview complement component C3a + complement component C3b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O C3 complement cleavage is a central event in the activation of the complement system via the classical, the alternative, and the lectin pathway, overview Homo sapiens complement component C3a + complement component C3b
-
 ?

Synonyms

Synonyms Comment Organism
C3 convertase
-
 Homo sapiens