Activating Compound | Comment | Organism | Structure |
---|---|---|---|
C3b | both the soluble form of the enzyme, C4b,C2a and the surface-bound form of the enzyme EAC1,C4b,C2a exhibit a poor affinity for the substrate C5. Very high affinity C5 convertase is generated only when the low affinity C3/C5 convertases are allowed to deposit C3b by cleaving native C3 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000011 | 0.0000083 | complement component C5 | 37°C, high-affinity C5 convertase EAC1,C3bC4b,C2a | Homo sapiens | |
0.0046 | 0.0066 | complement component C5 | 37°C, surface bound C3/C5 convertase, EAC1,C4b,C2a | Homo sapiens | |
0.0089 | - |
complement component C5 | 37°C, soluble monomeric C3/C5 convertase C4b,C2a | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | - |
Homo sapiens | complement component C3a + complement component C3b | - |
? | |
complement component C5 + H2O | - |
Homo sapiens | complement component C5a + complement component C5b | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C4b,C2a | soluble form of the enzyme | Homo sapiens |
classical pathway C3/C5 convertase | - |
Homo sapiens |
EAC1,C4b,C2a | surface-bound form of the enzyme | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | 0.026 | complement component C5 | 37°C, high-affinity C5 convertase EAC1,C3bC4b,C2a | Homo sapiens | |
0.022 | - |
complement component C5 | 37°C, soluble monomeric C3/C5 convertase C4b,C2a | Homo sapiens | |
0.023 | 0.047 | complement component C5 | 37°C, surface bound C3/C5 convertase, EAC1,C4b,C2a | Homo sapiens |