Literature summary for 3.4.21.42 extracted from

Almitairi, J.O.M.; Venkatraman Girija, U.; Furze, C.M.; Simpson-Gray, X.; Badakshi, F.; Marshall, J.E.; Schwaeble, W.J.; Mitchell, D.A.; Moody, P.C.E.; Wallis, R.
Structure of the C1r-C1s interaction of the C1 complex of complement activation (2018), Proc. Natl. Acad. Sci. USA, 115, 768-773 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Chinese hamster ovary cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
complex between the CUB1-EGF-CUB2 domains of C1r and C1s, sitting drop vapor diffusion method, in imidazole buffer at pH 8.0 with PEG 8000 as the precipitant	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	dependent on	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09871	-	-

Purification (Commentary)

Purification (Comment)	Organism
nickel-Sepharose affinity column chromatography and Superdex 200 gel filtration	Homo sapiens

Subunits

Subunits	Comment	Organism
homodimer	2 * 80000, component C1s, calculated from amino acid sequence	Homo sapiens

Synonyms

Synonyms	Comment	Organism
multiprotein complex C1	the multiprotein complex C1 is formed from the recognition subcomponent C1q and a tetramer of proteases C1r2C1s2	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	multiprotein complex C1 triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes	Homo sapiens

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Release 2023.1 (January 2023)