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Literature summary for 3.4.21.42 extracted from
- Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease a first-in-human trial (2019), Blood, 133, 893-901 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme inhibition with sutimlimab rapidly stopps hemolysis in patients with cold agglutinin disease | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sutimlimab | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C2 + H2O | Homo sapiens | - |
? | - |
? |  |
| complement component C4 + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C2 + H2O | - |
Homo sapiens | ? | - |
? | |
| complement component C4 + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C1s | - |
Homo sapiens |
| complement C1s | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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