Literature summary for 3.4.21.42 extracted from

Buerke, M.; Schwertz, H.; Seitz, W.; Meyer, J.; Darius, H.
Novel small molecule inhibitor of C1s exerts cardioprotective effects in ischemia-reperfusion injury in rabbits (2001), J. Immunol., 167, 5375-5380.

Search for more literature for 3.4.21.42

Application

Application	Comment	Organism
medicine	C1s-INH-248 is a highly selective small molecule inhibitor of complement subcomponent C1s. Blocking the classical complement pathway with a highly specific and potent synthetic inhibitor of the classical C1 complex appears to be an effective mean to preserve ischemic myocardium from injury following reperfusion	Homo sapiens
medicine	C1s-INH-248 is a highly selective small molecule inhibitor of complement subcomponent C1s. Blocking the classical complement pathway with a highly specific and potent synthetic inhibitor of the classical C1 complex appears to be an effective mean to preserve ischemic myocardium from injury following reperfusion	Oryctolagus cuniculus

Inhibitors

Inhibitors	Comment	Organism	Structure
C1s-INH-248	highly selective small molecule inhibitor. Blocking the classical complement pathway with a highly specific and potent synthetic inhibitor of the classical C1 complex appears to be an effective mean to preserve ischemic myocardium from injury following reperfusion	Homo sapiens
C1s-INH-248	highly selective small molecule inhibitor. Blocking the classical complement pathway with a highly specific and potent synthetic inhibitor of the classical C1 complex appears to be an effective mean to preserve ischemic myocardium from injury following reperfusion	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-
blood plasma	-	Oryctolagus cuniculus	-

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Release 2023.1 (January 2023)