General Stability | Organism |
---|---|
C1rbar undergoes autolytic cleavage | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Nitrophenyl-4-guanidinobenzoate | - |
Homo sapiens | |
Ca2+ | reaction with C1s | Homo sapiens | |
diisopropyl fluorophosphate | - |
Homo sapiens | |
leupeptin | competitive | Homo sapiens | |
additional information | high ionic strength inhibits | Homo sapiens | |
phenylmethylsulfonyl fluoride | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
MW of C1r: 166000-188000 Da, gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | autolytic proteolysis involves cleavage of the Arg279-Gly280 bond in the sequence Asp-Ser-Arg-Gly-Trp-Lys | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s + H2O | cleavage of a single Arg-Ile bond in the sequence Lys-Gln-Arg-Ile-Ile-Gly | Homo sapiens | complement component C1sbar | - |
? | |
N-acetyl-Gly-Lys methyl ester + H2O | - |
Homo sapiens | N-acetyl-Gly-Lys + methanol | - |
? | |
N-benzyloxycarbonyl-Gly-Arg thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
N-carbobenzoxy-Lys-p-nitrophenyl ester + H2O | - |
Homo sapiens | N-carbobenzoxy-Lys + 4-nitrophenyl | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | C1rbar and the proenzyme C1r are noncovalent dimers, the subunit of C1r has a MW of 53000-85000 Da, SDS-PAGE | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
high temperature transition occurs at 53°C, the low-temperature transition varies between 26°C at low ionic strength and 40°C in the presence of 0.5 M NaCl | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |