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Literature summary for 3.4.21.41 extracted from

  • Duncan, R.C.; Wijeyewickrema, L.C.; Pike, R.N.
    The initiating proteases of the complement system: controlling the cleavage (2008), Biochimie, 90, 387-395.
    View publication on PubMed
Search for more literature for 3.4.21.41

Inhibitors

Inhibitors Comment Organism Structure
C1-inhibitor regulates the classical and the lectin complement pathway inhibiting complement components C1r and C1s, and MASP-2, factor XIa, Factor XIIa, and plasma kallikrein, mechanism, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ binding of four Ca2+ per enzyme dimer Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
88000
-
 x * 88000, C1r zymogen, domain structure, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C1s + H2O Homo sapiens the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system activated complement component C1s + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens
proteolytic modification autoactivation of C1r as part of the C1 complex Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C1s + H2O the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system Homo sapiens activated complement component C1s + ?
-
 ?
complement component C1s + H2O C1r cleaves proenzyme C1s at an Arg-Ile bond in the serine domain Homo sapiens activated complement component C1s + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 88000, C1r zymogen, domain structure, overview Homo sapiens
More C1 complex structure Homo sapiens

Synonyms

Synonyms Comment Organism
C1r
-
 Homo sapiens