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Literature summary for 3.4.21.4 extracted from

  • Garcia Boy, R.; Mier, W.; Nothelfer, E.M.; Altmann, A.; Eisenhut, M.; Kolmar, H.; Tomaszowski, M.; Kraemer, S.; Haberkorn, U.
    Sunflower trypsin inhibitor 1 derivatives as molecular scaffolds for the development of novel peptidic radiopharmaceuticals (2009), Mol. Imaging Biol., 12, 377-385.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acyclic SFTI i.e. oSFTI, modified sunflower trypsin inhibitor 1, SFTI-1, generated by Fmoc-based automated synthesis Bos taurus
cMCoTI-II
-
Bos taurus
cyclic SFTI i.e. cSFTI, modified sunflower trypsin inhibitor 1, SFTI-1, generated by Fmoc-based automated synthesis Bos taurus
DOTA-SFTI modified sunflower trypsin inhibitor 1, SFTI-1, labeled, generated by Fmoc-based automated synthesis Bos taurus
oMCoTI-II
-
Bos taurus
sunflower trypsin inhibitor 1 SFTI-1, binding and effects on human prostate cancer cells, overview Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation standardized by active-site titration using 4-nitrophenyl-p9-guanidinobenzoate Bos taurus
-
pancreas
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Bos taurus N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000063
-
cMCoTI-II pH not specified in the publication, temperature not specified in the publication Bos taurus
0.00000008
-
cyclic SFTI pH not specified in the publication, temperature not specified in the publication Bos taurus
0.00000015
-
acyclic SFTI pH not specified in the publication, temperature not specified in the publication Bos taurus
0.0000003
-
DOTA-SFTI pH not specified in the publication, temperature not specified in the publication Bos taurus
0.00000043
-
oMCoTI-II pH not specified in the publication, temperature not specified in the publication Bos taurus