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Literature summary for 3.4.21.4 extracted from

  • Wu, P.; Weisell, J.; Pakkala, M.; Peraekylae, M.; Zhu, L.; Koistinen, R.; Koivunen, E.; Stenman, U.H.; Naervaenen, A.; Koistinen, H.
    Identification of novel peptide inhibitors for human trypsins (2010), Biol. Chem., 391, 283-293.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information identification of trypsin-3 binding peptides, and molecular modeling of the binding of peptides to isozyme trypsin-3. The degradation rate of peptides by trypsin correlates to their inhibitory efficacy, the most stable peptides being the most effective inhibitors, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes trypsin-1, -2, -C and -3
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information trypsin is produced as a proenzyme, trypsinogen, mainly by the pancreas, and it is activated in the gastrointestinal tract by enterokinase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information trypsinogen is expressed in various other healthy and malignant tissues Homo sapiens
-
pancreas trypsin is produced as a proenzyme, trypsinogen, mainly by the pancreas, and it is activated in the gastrointestinal tract by enterokinase Homo sapiens
-
small intestine
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-casein + H2O
-
Homo sapiens ?
-
?
additional information cleavage of the potentially inhibitory peptides by isozyme trypsin-3, substrate specificity, overview Homo sapiens ?
-
?
S-2222 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TRY-3
-
Homo sapiens
trypsin-3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

General Information

General Information Comment Organism
physiological function active trypsin participates in the digestion of food by degradation of dietary proteins and by activation of other digestive enzymes in the small intestine Homo sapiens