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Literature summary for 3.4.21.4 extracted from

  • Song, G.; Zhou, M.; Chen, W.; Chen, T.; Walker, B.; Shaw, C.
    HV-BBI--a novel amphibian skin Bowman-Birk-like trypsin inhibitor (2008), Biochem. Biophys. Res. Commun., 372, 191-196.
    View publication on PubMed
Search for more literature for 3.4.21.4

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by up to 0.05 mM SVIGCWTFSIPPRPCFVK-amide Homo sapiens
SVIGCWTKSIPPRPCFVK-amide HV-BBI is a Bowman-Birk type protease inhibitor from the skin secretion of the Chinese Bamboo odorous frog Huia versabilis, SVIGCWTKSIPPRPCFVK-amide is a synthetic replicate of HV-BBI with the wild-type K (Lys8) residue in the presumed P1 position and is a potent, competitive, and reversible inhibitor of trypsin Homo sapiens
SVIGCWTRSIPPRPCFVK-amide HV-BBI is a Bowman-Birk type protease inhibitor from the skin secretion of the Chinese Bamboo odorous frog Huia versabilis, SVIGCWTRSIPPRPCFVK-amide is a synthetic replicate of HV-BBI with the mutant R (Arg8) residue in the presumed P1 position and is a competitive, and reversible inhibitor of trypsin with reduced potency compared to the wild type peptide SVIGCWTKSIPPRPCFVK-amide Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Phe-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-Phe-L-Pro-L-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
alpha-trypsin
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000188
-
 SVIGCWTKSIPPRPCFVK-amide in 10 mM phosphate buffer, pH 7.4, containing 2.7 mM KCl and 137 mM NaCl, at 37°C Homo sapiens
0.0000542
-
 SVIGCWTRSIPPRPCFVK-amide in 10 mM phosphate buffer, pH 7.4, containing 2.7 mM KCl and 137 mM NaCl, at 37°C Homo sapiens