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Literature summary for 3.4.21.4 extracted from

  • Grishina, Z.; Ostrowska, E.; Halangk, W.; Sahin-Toth, M.; Reiser, G.
    Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1 (2005), Br. J. Pharmacol., 146, 990-999.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme pancreatic isoforms cationic trypsin and anionic trypsin show activity on human proteinase-activated receptors PAR-1, PAR-2, PAR-3 comparable to that of bovine pancreatic trypsin. Mesotrypsin cannot activate or disable proteinase-activated receptors in human epithelial cells, but activates PAR-1 in human astrocytoma cells ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 pancreatic isoforms cationic trypsin, anionic trypsin, and mesotrypsin
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Source Tissue

Source Tissue Comment Organism Textmining
pancreas isoforms cationic trypsin, anionic trypsin, and mesotrypsin Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme pancreatic isoforms cationic trypsin and anionic trypsin show activity on human proteinase-activated receptors PAR-1, PAR-2, PAR-3 comparable to that of bovine pancreatic trypsin. Mesotrypsin cannot activate or disable proteinase-activated receptors in human epithelial cells, but activates PAR-1 in human astrocytoma cells Homo sapiens ?
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 ?
proteinase-activated receptor PAR-1 + H2O no activation by mesotrypsin in epithelial cells, but mesotrypsin activates PAR-1 in astrocytoma cells. Half-maximal response for both cationic and anionic trypsin at about 10-20 nM Homo sapiens activated proteinase-activated receptor PAR-1
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 ?
proteinase-activated receptor PAR-2 + H2O no activation by mesotrypsin in epithelial cells. Half-maximal response for both cationic and anionic trypsin at about 5 nM Homo sapiens activated proteinase-activated receptor PAR-2
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 ?
proteinase-activated receptor PAR-3 + H2O no activation by mesotrypsin in epithelial cells. Half-maximal response for both cationic and anionic trypsin at about 10-20 nM Homo sapiens activated proteinase-activated receptor PAR-3
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 ?