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Literature summary for 3.4.21.4 extracted from
- Pancreatic trypsin cleaves intestinal alkaline sphingomyelinase from mucosa and enhances the sphingomyelinase activity (2004), Am. J. Physiol. Gastrointest. Liver Physiol., 287, G967-G973.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| intestinal alkaline sphingomyelinase bound to mucosa + H2O | Sus scrofa | cleavage at R440, first tryptic site upstream of signal anchor. Physiological role of enzyme in sphingomyelin digestion | free intestinal alkaline sphingomyelinase | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
commercial preparation | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| intestinal alkaline sphingomyelinase bound to mucosa + H2O | cleavage at R440, first tryptic site upstream of signal anchor. Physiological role of enzyme in sphingomyelin digestion | Sus scrofa | free intestinal alkaline sphingomyelinase | - |
? | |
| intestinal alkaline sphingomyelinase bound to mucosa + H2O | cleavage at R440, first tryptic site upstream of signal anchor | Sus scrofa | free intestinal alkaline sphingomyelinase | - |
? | |
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