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Literature summary for 3.4.21.39 extracted from

  • Futamura-Takahashi, J.; Tanaka, T.; Sugawara, H.; Iwashita, S.; Imajo, S.; Oyama, Y.; Muto, T.
    Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors (2018), Bioorg. Med. Chem. Lett., 28, 188-192 .
    View publication on PubMed
Search for more literature for 3.4.21.39

Inhibitors

Inhibitors Comment Organism Structure
2-amino-4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
-
 Homo sapiens
2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
-
 Homo sapiens
2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
-
 Homo sapiens
4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(2-methylpropoxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
-
 Homo sapiens
4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(cyclopentyloxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
-
 Homo sapiens
4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
-
 Homo sapiens
4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
-
 Homo sapiens
4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
-
 Homo sapiens
4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-[[(propan-2-yl)oxy]imino]-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P23946
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000089
-
 pH and temperature not specified in the publication Homo sapiens 2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
0.00005
-
 pH and temperature not specified in the publication Homo sapiens 4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
0.000078
-
 pH and temperature not specified in the publication Homo sapiens 2-amino-4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
0.00024
-
 pH and temperature not specified in the publication Homo sapiens 4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
0.0003
-
 pH and temperature not specified in the publication Homo sapiens 2-amino-4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
0.00057
-
 pH and temperature not specified in the publication Homo sapiens 4-[(1R)-1-([(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
0.00058
-
 pH and temperature not specified in the publication Homo sapiens 4-[(1R)-1-[[(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-7-oxo-3-[[(propan-2-yl)oxy]imino]-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acid
0.0012
-
 pH and temperature not specified in the publication Homo sapiens 4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(2-methylpropoxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid
0.0024
-
 pH and temperature not specified in the publication Homo sapiens 4-[(1R)-1-([(3E,6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3-[(cyclopentyloxy)imino]-7-oxo-1,4-diazepane-1-carbonyl]amino)propyl]benzoic acid