Cloned (Comment) | Organism |
---|---|
mutant enzymes asre expressed in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K192M | the mutant exhibits a markedly reduced sensitivity towards inhibitors compared to the wild type enzyme | Homo sapiens |
R143Q | the mutant exhibits a markedly reduced sensitivity towards inhibitors compared to the wild type enzyme | Homo sapiens |
R143Q/K192M | the mutant exhibits a markedly reduced sensitivity towards inhibitors compared to the wild type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[(5-fluoro-1-benzothiophen-3-yl)methyl]-3-{[(methoxycarbonyl)(methyl)amino]methyl}-1H-indole-2-carboxylate | - |
Homo sapiens | |
2-{1-[(1,4-dimethyl-1H-indol-3-yl)methyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}hexanoic acid | - |
Homo sapiens | |
4-({1-[(4-methyl-1-benzothiophen-3-yl)methyl]-1H-benzimidazol-2-yl}sulfanyl)butanoic acid | - |
Homo sapiens | |
TY51184 | - |
Homo sapiens | |
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonate | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
x * 26000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Homo sapiens | - |
angiotensin II + His-Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23946 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose beads chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O | - |
Homo sapiens | succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
mast cell chymase | - |
Homo sapiens |