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Literature summary for 3.4.21.39 extracted from

  • Beghdadi, W.; Madjene, L.C.; Claver, J.; Pejler, G.; Beaudoin, L.; Lehuen, A.; Daugas, E.; Blank, U.
    Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction (2013), Kidney Int., 84, 317-326.
    View publication on PubMed
Search for more literature for 3.4.21.39

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Mus musculus
-
 angiotensin II + His-Leu
-
 ?
Fibronectin + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P21812
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Mus musculus angiotensin II + His-Leu
-
 ?
Fibronectin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
mast cell protease 4
-
 Mus musculus
MCP4
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ,ice deficient in mouse mast cell protease 4 (MCP4) have increased obstruction-induced fibrosis when compared to wild type mice. Kidneys of MCP4-deficient mice have higher levels of renal tubular damage, interstitial fibrosis, collagen deposition, increased a-smooth muscle actin, and decreased E-cadherin expression compared to the kidneys of wild type mice Mus musculus
physiological function mast cell released mast cell protease 4 has anti-fibrotic potential in acutely induced obstructive nephropathy Mus musculus