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Literature summary for 3.4.21.39 extracted from
- Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism (2014), J. Immunol., 192, 1847-1854.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NK3201 | - |
Mus musculus |  |
| SUN C8077 | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P21812 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mast cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MC protease 4 | - |
Mus musculus |
| MCPT4 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | levels of inflammation and fibrosis are reduced in mast cell chymase MCPT4-deficient mice as compared with WT mice at day 7 after bleomycin-induced lung injury | Mus musculus |
| physiological function | MCPT4 chymase contributes to bleomycin-induced lung inflammation and fibrosis | Mus musculus |
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