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Literature summary for 3.4.21.39 extracted from

  • Nabe, T.; Kijitani, Y.; Kitagawa, Y.; Sakano, E.; Ueno, T.; Fujii, M.; Nakao, S.; Sakai, M.; Takai, S.
    Involvement of chymase in allergic conjunctivitis of guinea pigs (2013), Exp. Eye Res., 113, 74-79.
    View publication on PubMed
Search for more literature for 3.4.21.39

Application

Application Comment Organism
medicine chymase is a potential target for pharmacotherapy for allergic conjunctivitis Cavia porcellus

Inhibitors

Inhibitors Comment Organism Structure
ketotifen
-
 Cavia porcellus
ONO-WH-236 40 and 80 mg/kg used experimentally, potent and selective inhibition of chymase activity Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus A7WPL7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Cavia porcellus
-
ophthalmic lavage fluid
-
 Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
-
 Cavia porcellus N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000016
-
 pH and temperature not specified in the publication Cavia porcellus ONO-WH-236

Expression

Organism Comment Expression
Cavia porcellus chymase activity is increased in ophthalmic lavage fluid immediately after the pollen challenge up

General Information

General Information Comment Organism
physiological function chymase is released from mast cells after antigen challenge, followed by the induction of conjunctivitis symptoms through histamine release from mast cells Cavia porcellus