Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | chymase only accepts aromatic amino acids in position P1, with a strong preference for Tyr and Phe over Trp. Aliphatic amino acids are preferred in positions P2 to P4 N-terminal of the cleaved bond. In the P1' position C-terminal of the cleaved bond, Ser is clearly over-represented and acidic amino acids Asp and Glu are strongly preferred in the P2' position. In P3', the small aliphatic amino acids Ala, Val and Gly are frequently observed. | ? | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methoxysuccinyl-Arg-Ala-Tyr-4-nitroanilide + H2O | - |
Homo sapiens | methoxysuccinyl-Arg-Ala-Tyr + 4-nitroaniline | - |
? | |
additional information | chymase only accepts aromatic amino acids in position P1, with a strong preference for Tyr and Phe over Trp. Aliphatic amino acids are preferred in positions P2 to P4 N-terminal of the cleaved bond. In the P1' position C-terminal of the cleaved bond, Ser is clearly over-represented and acidic amino acids Asp and Glu are strongly preferred in the P2' position. In P3', the small aliphatic amino acids Ala, Val and Gly are frequently observed. | Homo sapiens | ? | - |
? |