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Literature summary for 3.4.21.38 extracted from
- Human Hageman factor and its fragments (1988), Methods Enzymol., 163, 68-80.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ala-Phe-Arg-chloromethylketone | - |
Homo sapiens |  |
| antithrombin III | - |
Homo sapiens | |
| C1 esterase inhibitor | - |
Homo sapiens | |
| dansyl-Glu-Gly-Arg-chloromethylketone | - |
Homo sapiens | |
| Phe-Phe-Arg-chloromethylketone | - |
Homo sapiens | |
| Phe-Pro-Arg-chloromethylketone | - |
Homo sapiens | |
| Pro-Phe-Arg chloromethylketone | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide | - |
Homo sapiens | |
| 0.021 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 8.0 | Homo sapiens | |
| 0.054 | - |
Pro-Phe-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
| 0.19 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 7.8, 0.117 M NaCl | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Pro-Phe-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
| Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg + 4-nitroaniline | - |
? | |
| Nalpha-benzoyl-Ile-Glu-OCH-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
| Nalpha-benzoyl-Ile-Glu-OH-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
| Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.9 | - |
Pro-Phe-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
| 14 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 8.0 | Homo sapiens | |
| 15 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 7.8, 0.117 M NaCl | Homo sapiens | |
| 23 | - |
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide | - |
Homo sapiens | |
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