Any feedback?
Literature summary for 3.4.21.38 extracted from
- Human factor XII (Hageman factor) (1981), Methods Enzymol., 80, 198-211.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 10000 | - |
the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 | Homo sapiens |
| 28000 | - |
the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 | Homo sapiens |
| 40000 | - |
the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 | Homo sapiens |
| 52000 | - |
the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | activation of the factor XII by proteolysis takes place in the presence of negatively charged materials. It is catalyzed by plasma enzymes, such as kallikrein, factor XIa and plasmin. Plasma kallikrein is probably the major activator under physiological conditions. High molecular weight kininogen stimulates the activation severalfold | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, stable for at least several months | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Pro-Phe-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | the human enzyme is a mixture of two forms, one form is composed of two chains, x * 28000 + x * 52000, a second enzyme form, x * 10000 + x * 28000 + x * 40000 | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
