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Literature summary for 3.4.21.38 extracted from
- Factor XII in coagulation, inflammation and beyond (2018), Cell. Signal., 51, 257-265 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-1-antitrypsin | - |
Mus musculus | |
| alpha-2-Antiplasmin | - |
Mus musculus | |
| alpha-2-Macroglobulin | - |
Mus musculus | |
| antithrombin III | - |
Mus musculus | |
| C1 esterase inhibitor | main physiological inhibitor | Mus musculus | |
| plasminogen activator inhibitor-1 | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XI + H2O | Mus musculus | - |
factor XIa + ? | - |
? | |
| prekallikrein + H2O | Mus musculus | - |
kallikrein + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Mus musculus | - |
| liver | the proenzyme is mainly produced in the liver | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XI + H2O | - |
Mus musculus | factor XIa + ? | - |
? | |
| prekallikrein + H2O | - |
Mus musculus | kallikrein + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 50000 + 1 * 28000, calculated from amino acid sequence | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alphaFXIIa | - |
Mus musculus |
| factor XIIa | - |
Mus musculus |
| FXIIa | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | genetic ablation of the enzyme protects against neuroinflammation, reduces the formation of atherosclerotic lesions in Apoe-deficient mice, improves wound healing, and inhibits postnatal angiogenesis | Mus musculus |
| physiological function | the enzyme initiates the intrinsic blood coagulation pathway via activation of factor XI, activates the kallikrein-kinin system leading to the release of bradykinin from high molecular weight kininogen, initiates fibrinolysis via proteinase K-mediated urokinase activation. The enzyme induces the expression of inflammatory mediators, promotes cell proliferation, and enhances the migration of neutrophils and lung fibroblasts | Mus musculus |
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Release 2023.1 (January 2023)
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