Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.38 extracted from

  • Sylman, J.; Daalkhaijav, U.; Zhang, Y.; Gray, E.; Farhang, P.; Chu, T.; Zilberman-Rudenko, J.; Puy, C.; Tucker, E.; Smith, S.; Morrissey, J.; Walker, T.; Nan, X.; Gruber, A.; McCarty, O.
    Differential roles for the coagulation factors XI and XII in regulating the physical biology of fibrin (2017), Ann. Biomed. Eng., 45, 1328-1340 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is activated when blood is exposed to negatively-charged foreign surfaces or molecules such as RNA, DNA, misfolded proteins, and polyphosphates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
corn trypsin inhibitor
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XI + H2O Homo sapiens
-
factor XIa + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XI + H2O
-
Homo sapiens factor XIa + ?
-
?

Synonyms

Synonyms Comment Organism
FXIIa
-
Homo sapiens

General Information

General Information Comment Organism
malfunction factor XII inhibition decreases the fibrin formation (5fold) and fibrin density, and increases the fibrinolysis rate when fibrin formation is initiated via the contact activation pathway with long-chain polyphosphate polyP Homo sapiens