Literature summary for 3.4.21.38 extracted from

MacQuarrie, J.L.; Stafford, A.R.; Yau, J.W.; Leslie, B.A.; Vu, T.T.; Fredenburgh, J.C.; Weitz, J.I.
Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation (2011), Blood, 117, 4134-4141.

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Inhibitors

Inhibitors	Comment	Organism	Structure
histidine-rich glycoprotein	inhibitor of autoactivation, inhibitor of activation of factor XI	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Biophen CS11-22 + H2O	-	Homo sapiens	?	-	?
factor XI + H2O	-	Homo sapiens	factor XIa + ?	-	?

Synonyms

Synonyms	Comment	Organism
factor XIIa	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000115	-	inhibitor of autoactivation, pH 7,4, 37°C	Homo sapiens	histidine-rich glycoprotein
0.000287	-	inhibitor of activation of factor XI, pH 7,4, 37°C	Homo sapiens	histidine-rich glycoprotein

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Release 2023.1 (January 2023)