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Literature summary for 3.4.21.38 extracted from

  • Kleinschnitz, C.; Stoll, G.; Bendszus, M.; Schuh, K.; Pauer, H.U.; Burfeind, P.; Renne, C.; Gailani, D.; Nieswandt, B.; Renne, T.
    Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis (2006), J. Exp. Med., 203, 513-518.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine after transient middle cerebral artery occlusion, the volume of infarcted brain in enzyme-deficient or enzyme-inhibitor treated mice is substantially less than in control, without an increase in infarct-associated hemorrhage Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme deletion mutant, protects mice from ischemic brain injury Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
PCK factor XIIa inhibitor, protects mice from ischemic brain injury Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme contributes to pathologic clotting through the intrinsic pathway ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme contributes to pathologic clotting through the intrinsic pathway Mus musculus ?
-
 ?