Literature summary for 3.4.21.37 extracted from

Dokai, M.; Madoiwa, S.; Yasumoto, A.; Kashiwakura, Y.; Ishiwata, A.; Sakata, A.; Makino, N.; Ohmori, T.; Mimuro, J.; Sakata, Y.
Local regulation of neutrophil elastase activity by endogenous alpha1-antitrypsin in lipopolysaccharide-primed hematological cells (2011), Thromb. Res., 128, 283-292.

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha1-antitrypsin	physiological inhibitor of neutrophil elastase. HL-60 cells neutralize neutrophil elastase activity by concomitant secretion of alpha1-antitrypsin	Homo sapiens
sivelestat sodium	neutrophil elastase specific inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	-	Homo sapiens	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
Elane	-	Homo sapiens
neutrophil elastase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzymatic activity of neutrophil elastase is markedly decreased until four hours after the stimulation with lipopolysaccharide	up

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Release 2023.1 (January 2023)