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Literature summary for 3.4.21.37 extracted from

  • Houghton, A.M.; Rzymkiewicz, D.M.; Ji, H.; Gregory, A.D.; Egea, E.E.; Metz, H.E.; Stolz, D.B.; Land, S.R.; Marconcini, L.A.; Kliment, C.R.; Jenkins, K.M.; Beaulieu, K.A.; Mouded, M.; Frank, S.J.; Wong, K.K.; Shapiro, S.D.
    Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth (2010), Nat. Med., 16, 219-223.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
ONO-5046
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin receptor substrate-1 + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin receptor substrate-1 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Elane
-
 Mus musculus
neutrophil elastase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function neutrophil elastase promotes lung tumor growth in vivo and induces tumor cell proliferation which is dependent upon platelet derived growth factor receptor-phosphtidylinositol-3 kinase signaling Mus musculus