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Literature summary for 3.4.21.37 extracted from

  • Lin, L.; Betsuyaku, T.; Heimbach, L.; Li, N.; Rubenstein, D.; Shapiro, S.D.; An, L.; Giudice, G.J.; Diaz, L.A.; Senior, R.M.; Liu, Z.
    Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid (2012), Matrix Biol., 31, 38-44.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Alpha1-proteinase inhibitor
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BP180/type XVII collagen + H2O Mus musculus neutrophil elastase degrades recombinant mouse BP180 within the immunodominant extracellular domain at amino acid positions 506 and 561 peptide p561 + peptide p506
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BP180/type XVII collagen + H2O neutrophil elastase degrades recombinant mouse BP180 within the immunodominant extracellular domain at amino acid positions 506 and 561 Mus musculus peptide p561 + peptide p506
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mice lacking neutrophil elastase do not develop experimental Mus musculus
physiological function neutrophil elastase directly damages the extracellular matrix and neutrophil elastase degradation of mouse BP180 generates neutrophil chemotactic peptides that amplify disease severity at the early stage of bullous pemphigoid. Local injection of neutrophil elastase induces neutrophil infiltration Mus musculus