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Literature summary for 3.4.21.37 extracted from

  • Fang, H.; Sun, C.; Xu, L.; Owen, R.J.; Auth, R.D.; Snoy, P.J.; Frucht, D.M.
    Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract (2010), J. Immunol., 185, 5463-5467.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin + H2O
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Mus musculus N-methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus neutrophils isolated from mice treated with anthrax lethal toxin in vivo and cultured ex vivo release greater amounts of neutrophil elastase than neutrophils from vehicle-treated controls up

General Information

General Information Comment Organism
malfunction neutrophil elastase deficient mice have a significant survival advantage over wild type animals following exposure to anthrax lethal toxin Mus musculus
physiological function neutrophil elastase plays a key role in mediating the deleterious effects of anthrax lethal toxin. There is a marked lethal toxin-induced intestinal ulceration and bleeding in wild type neutrophil elastase animals Mus musculus