Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | N-methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | neutrophils isolated from mice treated with anthrax lethal toxin in vivo and cultured ex vivo release greater amounts of neutrophil elastase than neutrophils from vehicle-treated controls | up |
General Information | Comment | Organism |
---|---|---|
malfunction | neutrophil elastase deficient mice have a significant survival advantage over wild type animals following exposure to anthrax lethal toxin | Mus musculus |
physiological function | neutrophil elastase plays a key role in mediating the deleterious effects of anthrax lethal toxin. There is a marked lethal toxin-induced intestinal ulceration and bleeding in wild type neutrophil elastase animals | Mus musculus |