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Literature summary for 3.4.21.37 extracted from

  • Dou, D.; He, G.; Kuang, R.; Fu, Q.; Venkataraman, R.; Groutas, W.C.
    Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase (2010), Bioorg. Med. Chem., 18, 6646-6650.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-benzoylphenyl)propanoate
-
 Homo sapiens
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-phenoxyphenyl)propanoate
-
 Homo sapiens
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(acetyloxy)benzoate
-
 Homo sapiens
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-hydroxybenzoate
-
 Homo sapiens
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-[4-(propan-2-yl)phenyl]propanoate
-
 Homo sapiens
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 3-phenylpropanoate
-
 Homo sapiens
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl phenylacetate
-
 Homo sapiens
[(4S)-5-benzyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl [2-[(2,6-dichlorophenyl)amino]phenyl]acetate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-benzoylphenyl)propanoate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(4-phenoxyphenyl)propanoate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-(acetyloxy)benzoate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-hydroxybenzoate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 2-[4-(propan-2-yl)phenyl]propanoate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl 3-phenylpropanoate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl phenylacetate
-
 Homo sapiens
[(4S)-5-methyl-4-(2-methylpropyl)-1,1-dioxido-3-oxo-1,2,5-thiadiazolidin-2-yl]methyl [2-[(2,6-dichlorophenyl)amino]phenyl]acetate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?
N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Val + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
HNE
-
 Homo sapiens
neutrophil elastase
-
 Homo sapiens