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Literature summary for 3.4.21.37 extracted from
- Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats (2010), Transl. Res., 155, 294-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-658758 | the neutrophil elastase inhibitor prevents ischemia/reperfusion-induced decreases of hepatic tissue levels of CGRP and IGF-I | Rattus norvegicus |  |
| sivelestat | the neutrophil elastase inhibitor prevents ischemia/reperfusion-induced decreases of hepatic tissue levels of CGRP and IGF-I | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| neutrophil | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| neutrophil elastase | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | neutrophil elastase decreases the endothelial production of prostacyclin through the inhibition of endothelial nitric oxide synthase activation and thereby contributes to the development of ischemia/reperfusion-induced liver injury. Neutrophil elastase may play a critical role in the development of I/R-induced liver injury by decreasing the IGF-I production through the inhibition of sensory neuron stimulation, which may lead to an increase of neutrophil accumulation and hepatic apoptosis through activation of caspase-3 in rats, overview | Rattus norvegicus |
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