Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.37 extracted from

  • Stowe, A.M.; Adair-Kirk, T.L.; Gonzales, E.R.; Perez, R.S.; Shah, A.R.; Park, T.S.; Gidday, J.M.
    Neutrophil elastase and neurovascular injury following focal stroke and reperfusion (2009), Neurobiol. Dis., 35, 82-90.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Activating Compound

Activating Compound Comment Organism Structure
additional information stroke increases tissue neutrophil elastase activity and expression Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information genetic deletion of neutrophil elastase significantly reduce infarct volume, blood-brain barrier disruption, vasogenic edema, and leukocyte-endothelial adherence after transient middle cerebral artery occlusion Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ZN200355 pharmacologic inhibition of neutrophil elastase significantly reduces infarct volume, blood-brain barrier disruption, vasogenic edema, and leukocyte-endothelial adherence after transient middle cerebral artery occlusion Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type 129SvEv mice and mutant mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
endothelial cell
-
 Mus musculus
-
leukocyte
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus stroke increases tissue neutrophil elastase activity and expression up

General Information

General Information Comment Organism
malfunction pharmacologic inhibition of neutrophil elastase and genetic deletion significantly reduce infarct volume, blood-brain barrier disruption, vasogenic edema, and leukocyte-endothelial adherence after transient middle cerebral artery occlusion Mus musculus