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Literature summary for 3.4.21.37 extracted from

  • Ho, S.C.; Lee, K.Y.; Chan, Y.F.; Kuo, L.W.; Ito, K.; Adcock, I.M.; Chen, B.C.; Sheu, J.R.; Lin, C.H.; Kuo, H.P.
    Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor (2009), J. Immunol., 183, 411-420.
    View publication on PubMed
Search for more literature for 3.4.21.37

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
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 Homo sapiens
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens neutrophil elastase induces NF-kappaB activation by p65 in airway smooth muscle, which leads to induction of TGF-beta1. Neutrophil elastase suppresses NF-kappaB response gene IL-8/CXCL8 release and mRNA expression in airway smooth muscle cells at the transcription level mediated by induction of NF-kappaB repressing factor, NRF. In A549 and Beas-2B cells, neutrophil elastase only stimulates NF-kappaB activation by p65 and IL-8/CXCL8 induction, but not NRF, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
lung
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 Homo sapiens
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neutrophil
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 Homo sapiens
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respiratory smooth muscle
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neutrophil elastase induces NF-kappaB activation by p65 in airway smooth muscle, which leads to induction of TGF-beta1. Neutrophil elastase suppresses NF-kappaB response gene IL-8/CXCL8 release and mRNA expression in airway smooth muscle cells at the transcription level mediated by induction of NF-kappaB repressing factor, NRF. In A549 and Beas-2B cells, neutrophil elastase only stimulates NF-kappaB activation by p65 and IL-8/CXCL8 induction, but not NRF, overview Homo sapiens ?
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 ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
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 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
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 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
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 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
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 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens