Literature summary for 3.4.21.37 extracted from

Kobayashi, M.; Irinoda, T.; Akiyama, Y.; Meguro, E.; Hayakawa, Y.; Funato, O.; Takagane, A.
Effect of a selective neutrophil elastase inhibitor on early recovery from body water imbalance after transthoracic esophagectomy (2010), Dis. Esophagus, 23, 565-571.

Search for more literature for 3.4.21.37

Inhibitors

Inhibitors	Comment	Organism	Structure
sivelestat	a selective neutrophil elastase inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	Japanese population	-

Synonyms

Synonyms	Comment	Organism
neutrophil elastase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	esophagectomy with elective lymphadenectomy may induce excessive release of neutrophil elastase	up

General Information

General Information	Comment	Organism
malfunction	esophagectomy with elective lymphadenectomy may induce excessive release of neutrophil elastase, which then promotes vascular permeability and an excessive water shift from the intravascular space to the peripheral compartment. Body fluid imbalance after esophagectomy often leads to circular instability, a decrease of urine output, and a delay in the shift to a diuretic state. Treatment with inhibitor sivelastat shortens the shift to a diuretic state and leads to a shorter operation time, the incidence of delayed respiratory dysfunction is also significantly lower	Homo sapiens

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Release 2023.1 (January 2023)