Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchoalveolar lavage | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | increased neutrophil elastase activity and oxidative stress in the lung can lead to alpha-1-antitrypsin deficiency, A1AT deficiency. Neutrophil elastase digests ferritin increasing the extracellular iron pool available for cellular uptake, it generates reactive oxygen species by increasing lung nonheme iron. Phenotypes of A1AT deficiency patinets and of rats with lungs injured with human neutrophil elastase, overview. The rats show iron-laden macrophages at day 28, but no sideromacrophages | Homo sapiens |