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Literature summary for 3.4.21.37 extracted from

  • Huang, W.; Yamamoto, Y.; Li, Y.; Dou, D.; Alliston, K.R.; Hanzlik, R.P.; Williams, T.D.; Groutas, W.C.
    X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives (2008), J. Med. Chem., 51, 2003-2008.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method, using 0.1 M HEPES (pH 7.5) and 20% PEG8000 or in 0.1 M HEPES (pH 7.5) and 35% PEG8000 containing 10 mM N-methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone inhibitor Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,2,5-thiadiazolidin-3-one 1,1-dioxide the inhibitor causes rapid, time-dependent, irreversible loss of enzymatic activity Homo sapiens
N-methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000574
-
1,2,5-thiadiazolidin-3-one 1,1-dioxide
-
Homo sapiens