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Literature summary for 3.4.21.37 extracted from

  • Kelly, E.; Greene, C.M.; McElvaney, N.G.
    Targeting neutrophil elastase in cystic fibrosis (2008), Expert Opin. Ther. Targets, 12, 145-157.
    View publication on PubMed
Search for more literature for 3.4.21.37

Application

Application Comment Organism
medicine neutrophil elastase is a target fot therapies in the treatment of cystic fibrosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-1-antitrypsin
-
 Homo sapiens
antipain
-
 Homo sapiens
chymostatin
-
 Homo sapiens
eglin-c
-
 Homo sapiens
elafin cationic protease inhibitor of human neutrophil elastase Homo sapiens
elasnin
-
 Homo sapiens
EPI-hNE-4 potent and specific inhibitor of neutrohil elastase Homo sapiens
erythromycin acts as an alternate substrate neutrophil elastase inhibitor Homo sapiens
flurythromycin inactivator of neutrophil elastase Homo sapiens
greglin fast-acting and tight-binding inhibitor of neutrophil elastase Homo sapiens
human monocyte/neutrophil elastase inhibitor effective inhibition Homo sapiens
L-658758
-
 Homo sapiens
leupeptin
-
 Homo sapiens
oleic acid
-
 Homo sapiens
secretory leukoprotease inhibitor
-
 Homo sapiens
valinal
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
primary granule
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coagulation factor V + H2O Homo sapiens
-
 ?
-
 ?
coagulation factor VIII + H2O Homo sapiens
-
 ?
-
 ?
coagulation factor XI + H2O Homo sapiens
-
 ?
-
 ?
coagulation factor XIII + H2O Homo sapiens
-
 ?
-
 ?
Collagen type I + H2O Homo sapiens
-
 ?
-
 ?
collagen type II + H2O Homo sapiens
-
 ?
-
 ?
Collagen type III + H2O Homo sapiens
-
 ?
-
 ?
collagen type IV + H2O Homo sapiens
-
 ?
-
 ?
collagenase + H2O Homo sapiens
-
 ?
-
 ?
complement factor C3 + H2O Homo sapiens
-
 ?
-
 ?
complement factor C5 + H2O Homo sapiens
-
 ?
-
 ?
complement receptor + H2O Homo sapiens
-
 ?
-
 ?
elafin + H2O Homo sapiens
-
 ?
-
 ?
Elastin + H2O Homo sapiens
-
 ?
-
 ?
Fibrinogen + H2O Homo sapiens
-
 ?
-
 ?
Fibronectin + H2O Homo sapiens
-
 ?
-
 ?
Gelatinase + H2O Homo sapiens
-
 ?
-
 ?
gp120 protein + H2O Homo sapiens
-
 ?
-
 ?
immunoglobulin A + H2O Homo sapiens
-
 ?
-
 ?
immunoglobulin G + H2O Homo sapiens
-
 ?
-
 ?
immunoglobulin M + H2O Homo sapiens
-
 ?
-
 ?
intercellular adhesion molecule-1 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-1 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-2 + H2O Homo sapiens
-
 ?
-
 ?
interleukin-6 + H2O Homo sapiens
-
 ?
-
 ?
kininogen + H2O Homo sapiens
-
 ?
-
 ?
Laminin + H2O Homo sapiens
-
 ?
-
 ?
lung surfactant + H2O Homo sapiens
-
 ?
-
 ?
plasminogen + H2O Homo sapiens
-
 ?
-
 ?
platelet IIb/IIIa receptor + H2O Homo sapiens
-
 ?
-
 ?
Proteoglycan + H2O Homo sapiens
-
 ?
-
 ?
thrombomodulin + H2O Homo sapiens
-
 ?
-
 ?
tissue inhibitor of metalloprotease + H2O Homo sapiens
-
 ?
-
 ?
tissue necrosis factor alpha + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coagulation factor V + H2O
-
 Homo sapiens ?
-
 ?
coagulation factor VIII + H2O
-
 Homo sapiens ?
-
 ?
coagulation factor XI + H2O
-
 Homo sapiens ?
-
 ?
coagulation factor XIII + H2O
-
 Homo sapiens ?
-
 ?
Collagen type I + H2O
-
 Homo sapiens ?
-
 ?
collagen type II + H2O
-
 Homo sapiens ?
-
 ?
Collagen type III + H2O
-
 Homo sapiens ?
-
 ?
collagen type IV + H2O
-
 Homo sapiens ?
-
 ?
collagenase + H2O
-
 Homo sapiens ?
-
 ?
complement factor C3 + H2O
-
 Homo sapiens ?
-
 ?
complement factor C5 + H2O
-
 Homo sapiens ?
-
 ?
complement receptor + H2O
-
 Homo sapiens ?
-
 ?
elafin + H2O
-
 Homo sapiens ?
-
 ?
Elastin + H2O
-
 Homo sapiens ?
-
 ?
Fibrinogen + H2O
-
 Homo sapiens ?
-
 ?
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
Gelatinase + H2O
-
 Homo sapiens ?
-
 ?
gp120 protein + H2O
-
 Homo sapiens ?
-
 ?
immunoglobulin A + H2O
-
 Homo sapiens ?
-
 ?
immunoglobulin G + H2O
-
 Homo sapiens ?
-
 ?
immunoglobulin M + H2O
-
 Homo sapiens ?
-
 ?
intercellular adhesion molecule-1 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-1 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-2 + H2O
-
 Homo sapiens ?
-
 ?
interleukin-6 + H2O
-
 Homo sapiens ?
-
 ?
kininogen + H2O
-
 Homo sapiens ?
-
 ?
Laminin + H2O
-
 Homo sapiens ?
-
 ?
lung surfactant + H2O
-
 Homo sapiens ?
-
 ?
plasminogen + H2O
-
 Homo sapiens ?
-
 ?
platelet IIb/IIIa receptor + H2O
-
 Homo sapiens ?
-
 ?
Proteoglycan + H2O
-
 Homo sapiens ?
-
 ?
thrombomodulin + H2O
-
 Homo sapiens ?
-
 ?
tissue inhibitor of metalloprotease + H2O
-
 Homo sapiens ?
-
 ?
tissue necrosis factor alpha + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens
-
-
 9.4